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Domperidone
API

Domperidone is used in formulations that require enhanced solubility and rapid release due to its poor aqueous solubility

HUMAN API

Domperidone

Domperidone is a crucial Active Pharmaceutical Ingredient (API) belonging to the Dopamine Antagonists class. It is primarily used as an Anti-emetic (to prevent vomiting) and a Prokinetic Agent (to enhance gastrointestinal motility). It works by accelerating gastric emptying and alleviating nausea and vomiting. We supply Domperidone in high-purity grades to ensure efficacy and stability across various pharmaceutical dosage forms.

The product conforms to the specified requirements of the United States Pharmacopeia (USP), European Pharmacopoeia (EP), and/or British Pharmacopoeia (BP).
A detailed CoA is issued with every batch, outlining potency, purity profile, and microbiological testing verification.
A comprehensive Drug Master File is available to support registration submissions to regulatory authorities worldwide.
Production takes place in certified facilities that strictly adhere to current Good Manufacturing Practices (cGMP).
Therapeutic Class:
Anti-emetic and Prokinetic Agent.
Mechanism of Action:
Selectively blocks peripheral D2 dopamine receptors in the Chemoreceptor Trigger Zone (CTZ) and the stomach wall, thereby promoting gastrointestinal motility and reducing nausea.
Clinical Application:
Treatment of nausea and vomiting from various causes, and symptomatic relief of digestive issues caused by delayed gastric emptying.
Competitive Advantage:
Does not significantly cross the blood-brain barrier, which minimizes central nervous system (CNS) side effects compared to some other dopamine antagonists.
Oral Tablets

Immediate- and extended-release tablets, and orally dispersible tablets (ODTs).

Supplied in grades with excellent flow and cohesiveness for standard compression and filling processes.

Liquid Formulations

Suspensions and syrups for pediatric use.

Excellent stability in liquid media, suitable for formulations requiring a homogeneous suspension.

Suppositories

For use in situations where oral administration is not feasible (severe vomiting).

Good compatibility with common suppository bases and appropriate purity grade.

Regulatory Compliance

The product conforms to the specified requirements of the United States Pharmacopeia (USP), European Pharmacopoeia (EP), and/or British Pharmacopoeia (BP).

Certificate of Analysis (CoA)

A detailed CoA is issued with every batch, outlining potency, purity profile, and microbiological testing verification.

Drug Master File (DMF)

A comprehensive Drug Master File is available to support registration submissions to regulatory authorities worldwide.

Manufacturing Operations

Production takes place in certified facilities that strictly adhere to current Good Manufacturing Practices (cGMP).

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